Year : 2016 | Volume
: 53 | Issue : 4 | Page : 258--262
Hormonal profile and clinical characteristics of epileptic females with abnormal ovarian morphology
Asmaa M Ebraheim1, Reham M Shamloul1, Soha Talaat2
1 Department of Neurology, Cairo University, Cairo, Egypt
2 Department of Radiology, Cairo University, Cairo, Egypt
Women with epilepsy (WWE) tend to have ovarian echographic abnormalities, raising concerns about an interaction between the brain and the ovaries.
This study aims to determine the relationship between abnormal ovarian follicular morphology as detected by ultrasonography (US) and clinical features, hormonal profile, and antiepileptic drugs (AEDs) in epileptic females.
Participants and methods
WWE who attended Kasr Al-Ainy Epilepsy Clinic and fulfilled the inclusion criteria were recruited and assessed clinically. Transabdominal US of the ovaries and the uterus was performed; in addition, serum levels for luteinizing hormone (LH), follicle-stimulating hormone, estradiol, testosterone, and fasting insulin were determined for all the participants. Thirteen WWE who had ovarian echographic abnormalities were compared with 67 epileptic females with normal ovarian US.
Significantly elevated LH was detected in patients with ovarian morphologic abnormality compared with the control group. The clinical parameters, the frequency of use of different AEDs, and the mean values of the other hormones were comparable in both groups.
Elevated LH in patients with an ovarian echographic abnormality points to altered gonadotropin secretion in these patients, which could be explained by the effect of epileptic discharges on the hypothalamus, but not the use of AEDs.
Asmaa M Ebraheim
Department of Neurology, Cairo University, Cairo
|How to cite this article:|
Ebraheim AM, Shamloul RM, Talaat S. Hormonal profile and clinical characteristics of epileptic females with abnormal ovarian morphology.Egypt J Neurol Psychiatry Neurosurg 2016;53:258-262
|How to cite this URL:|
Ebraheim AM, Shamloul RM, Talaat S. Hormonal profile and clinical characteristics of epileptic females with abnormal ovarian morphology. Egypt J Neurol Psychiatry Neurosurg [serial online] 2016 [cited 2023 Dec 10 ];53:258-262
Available from: http://www.ejnpn.eg.net/article.asp?issn=1110-1083;year=2016;volume=53;issue=4;spage=258;epage=262;aulast=Ebraheim;type=0