The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 53  |  Issue : 4  |  Page : 238--243

Role of interleukin-6 in refractory epilepsy


Nervana M El-Fayoumy1, Hatem A El-Massry2, Montasser M Hegazy1, Amany H Ragab1, Rabab A Mohamed3, Sara G Abdel Alim2 
1 Department of Neurology, Cairo University, Cairo, Egypt
2 Department of Neurology, Beni Suef University, Beni Suef, Egypt
3 Department of Clinical and Chemical Pathology, Beni Suef University, Beni Suef, Egypt

Correspondence Address:
Amany H Ragab
Department of Neurology, Cairo University, 11728
Egypt

Background There is increasing evidence of a complex relationship between epilepsy and the immune system. Objective The aim of this study was to ascertain the relationship between inflammatory cytokines, immune system dysregulation, and the pathogenesis of refractory epilepsy by determining the level of interleukin-6 (IL-6) in patients with refractory epilepsy and its relation to different factors. Patients and methods This study was conducted on 30 patients with refractory epilepsy and 10 healthy control participants. All patients were assessed using clinical evaluation, conventional digital electroencephalogram, brain MRI, routine laboratory tests, and IL-6 level in serum. Results Serum IL-6 level was significantly higher in patients with refractory epilepsy than in the control group. Conclusion There is a significant association between serum IL-6 level and refractory epilepsy.


How to cite this article:
El-Fayoumy NM, El-Massry HA, Hegazy MM, Ragab AH, Mohamed RA, Abdel Alim SG. Role of interleukin-6 in refractory epilepsy.Egypt J Neurol Psychiatry Neurosurg 2016;53:238-243


How to cite this URL:
El-Fayoumy NM, El-Massry HA, Hegazy MM, Ragab AH, Mohamed RA, Abdel Alim SG. Role of interleukin-6 in refractory epilepsy. Egypt J Neurol Psychiatry Neurosurg [serial online] 2016 [cited 2021 Dec 7 ];53:238-243
Available from: http://www.ejnpn.eg.net/article.asp?issn=1110-1083;year=2016;volume=53;issue=4;spage=238;epage=243;aulast=El-Fayoumy;type=0