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Year : 2016  |  Volume : 53  |  Issue : 4  |  Page : 238-243

Role of interleukin-6 in refractory epilepsy

1 Department of Neurology, Cairo University, Cairo, Egypt
2 Department of Neurology, Beni Suef University, Beni Suef, Egypt
3 Department of Clinical and Chemical Pathology, Beni Suef University, Beni Suef, Egypt

Correspondence Address:
Amany H Ragab
Department of Neurology, Cairo University, 11728
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-1083.202384

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Background There is increasing evidence of a complex relationship between epilepsy and the immune system. Objective The aim of this study was to ascertain the relationship between inflammatory cytokines, immune system dysregulation, and the pathogenesis of refractory epilepsy by determining the level of interleukin-6 (IL-6) in patients with refractory epilepsy and its relation to different factors. Patients and methods This study was conducted on 30 patients with refractory epilepsy and 10 healthy control participants. All patients were assessed using clinical evaluation, conventional digital electroencephalogram, brain MRI, routine laboratory tests, and IL-6 level in serum. Results Serum IL-6 level was significantly higher in patients with refractory epilepsy than in the control group. Conclusion There is a significant association between serum IL-6 level and refractory epilepsy.

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