| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 53
| Issue : 4 | Page : 238-243 |
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Role of interleukin-6 in refractory epilepsy
Nervana M El-Fayoumy1, Hatem A El-Massry2, Montasser M Hegazy1, Amany H Ragab MD 1, Rabab A Mohamed3, Sara G Abdel Alim2
1 Department of Neurology, Cairo University, Cairo, Egypt
2 Department of Neurology, Beni Suef University, Beni Suef, Egypt
3 Department of Clinical and Chemical Pathology, Beni Suef University, Beni Suef, Egypt
Correspondence Address:
Amany H Ragab
Department of Neurology, Cairo University, 11728
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1110-1083.202384
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Background
There is increasing evidence of a complex relationship between epilepsy and the immune system.
Objective
The aim of this study was to ascertain the relationship between inflammatory cytokines, immune system dysregulation, and the pathogenesis of refractory epilepsy by determining the level of interleukin-6 (IL-6) in patients with refractory epilepsy and its relation to different factors.
Patients and methods
This study was conducted on 30 patients with refractory epilepsy and 10 healthy control participants. All patients were assessed using clinical evaluation, conventional digital electroencephalogram, brain MRI, routine laboratory tests, and IL-6 level in serum.
Results
Serum IL-6 level was significantly higher in patients with refractory epilepsy than in the control group.
Conclusion
There is a significant association between serum IL-6 level and refractory epilepsy. |
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