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Year : 2016  |  Volume : 53  |  Issue : 2  |  Page : 89-95

Site and degree of intracranial arterial stenosis in acute stroke patients with metabolic syndrome among a sample of Egyptian patients

1 Department of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Department of Endocrinology; Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Doaa A Elaidy
MD, Departments of Neurology and Psychiatry, Ain Shams University, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-1083.183409

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Background Type 2 diabetes mellitus (T2DM) has various effects on the vascular tree, both macrovascular and microvascular and both intracranial and extracranial circulation. Metabolic syndrome is a combination of medical disorders that, when occurring together, increases the risk of developing cardiovascular diseases including stroke. Objectives In this study, we aimed to estimate the site and degree of intracranial arterial stenosis among patients clinically diagnosed as acute ischemic stroke patients with metabolic syndrome with or without T2DM. Patients and methods This cross-sectional study included 100 patients admitted in Ain Shams University Specialized Hospital-Stroke Unit with the diagnosis of clinically first-ever cerebral infarction and metabolic syndrome with or without T2DM. All patients were subjected to detailed medical history, thorough general and neurological examination, full laboratory investigations, computerized tomography, MRI, and magnetic resonance angiography of the brain, carotid duplex, ECG, and echocardiography. Results Small vessel disease (lacune) was present more frequently in patients with T2DM than in those without T2DM, and this showed a statistically significant difference (P = 0.008). It was found that intracranial stenosis was statistically significantly higher compared with extracranial carotid stenosis in patients with T2DM with total or near-total occlusion, with P values less than 0.05. These stenoses or occlusions also tend to be multiple in the same group of patients with T2DM (P = 0.033). Conclusion Diabetic patients with acute ischemic stroke have a higher severity of intracranial arterial stenosis, higher incidence of multiple intracranial arterial stenoses, and lastly higher tendency to have obstructive intracranial arterial lesions.

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